— Determining the three-dimensional structure of biomolecules in solutions, using internuclear geometric constraints (torsional angles, internuclear distances, RDCs).
— Determining the three-dimensional structure of ligands within complexes: ligand - protein, carbohydrate - protein, ligand - RNA/DNA, etc. (STD, Transfer NOE, Transfer RDC).
— Determining the structure of ligand receptors complexes.
— Determining the stability constants of biomolecular interactions.
— Analysis of mass variation close to a surface over which proteins are immobilized by modifying the composition of a solution.
— Determining association kA and dissociation kD kinetic parameters, enabling the calculation of the thermodynamic equilibrium constant (KD).
— The system allows the measuring of molecules surface affinities, and includes a CCD video camera to record images in real time from an array that can hold up to 400 Biomolecular interactions on the biochip functionalized surface.
Differential Scanning Calorimetry (DSC)
— Determining heats and temperatures of thermal transitions
• glass transitions
• "cold" crystallization
• phase changes
— Determining heat capacities and stability of dilute solutions
— Analysis of biomolecular interactions
Isothermal Titration Calorimetry (ITC)
— Determining dissociation constants and stoichiometry in binding phenomena
— Determining the thermodynamic parameters for binding
— Analysis of ionization phenomena
— Determining micelle critical concentrations
— Reaction kinetics
— Determining the molecular mass by detecting time of flight (TOF) with laser desorption ionization (MALDI), being possible to work in linear and reflectron mode.
— Determining the particle size ranging between 0.3 nm and 10 µm by Dynamic Light Scattering.
— Determining the molecular weights between 103 and 2 x 107 Dalton by Static Light Scattering.
— Determining the of zeta potential using M3-PALS technology.
Actualización tabla de precios de los servicios BIP
9 July 2018
Inicio facturación del Servicio de FPLC
6 July 2018
Nuevo acceso a los servicios BIP
15 March 2018
Seminario avanzado de FPLC
9 March 2018
Facturación del Servicio de Maldi-Tof
2 May 2017
El equipo de RMN ya está activo
24 February 2017