Description

The NMR600 service features a liquid sample instrument equipped with a 600 MHz ASCEND magnet, an AVANCE III HD console, a cryogenic platform, a high-performance cryoprobe and a cooled ²H preamplifier for excellent stability. The quadrupole cryoprobe is equipped with an actively shielded single-axis Z-gradient for 5 mm sample diameters and features four fully independent channels ¹H,¹³C , ¹⁵N and ¹⁹F (plus ²H lock channel) with simultaneous decoupling capability on multiple X-nuclei such as ¹³C, ¹⁹F and ¹⁵N. The cryoprobe is optimized for ¹H, ¹⁹F and ¹³C detection with an increase in sensitivity by a factor of three, ideal for the study of ¹⁹F applications.
Applications range from structural elucidation and conformational analysis of synthetic organic molecules and biomolecules to protein-ligand interaction studies (ligand-based and/or protein-based interaction studies providing ligand screening for a given receptor, ligand-binding epitopes, 3D protein structure and dynamics, protein-ligand affinities…). The high sensitivity for ¹⁹F detection makes the system an excellent tool for studies of fluorinated molecules even under challenging low concentration conditions, as well as for protein screening of fluorinated compound libraries.

Users are encouraged to carefully read the General Rules for Access and Use.

Documents